https://hmpublisher.com/index.php/OAIJMR <p><strong>Open Access Indonesian Journal of Medical Reviews (OAIJMR)&nbsp;</strong>is a bi-monthly, international, peer-review, and open access journal dedicated to various disciplines of medicine, biology and life sciences. The journal publishes all type of review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review. <strong>OAIJMR</strong> is an official journal of&nbsp;<a href="https://cattleyacenter.id/" target="_blank" rel="noopener">CMHC (Research &amp; Sains Center)</a>&nbsp;and &nbsp;<a href="https://cattleyapublicationservices.com/hanifmedisiana/" target="_blank" rel="noopener">HM Publisher</a>. <strong>OAIJMR</strong> has <a href="https://issn.brin.go.id/terbit/detail/20210827121715854" target="_blank" rel="noopener">electronic ISSN (eISSN) : 2807-6257</a>. <strong>OAIJMR</strong> has <a href="https://portal.issn.org/resource/ISSN/2807-6257#" target="_blank" rel="noopener">International ISSN (ROAD) : 2807-6257</a>.</p> HM Publisher en-US Open Access Indonesian Journal of Medical Reviews 2807-6257 <p><strong>Open Access Indonesian Journal of Medical Reviews (OAIJMR)&nbsp;</strong>allow the author(s) to hold the copyright without restrictions and&nbsp; allow the author(s) to retain publishing rights without restrictions, also the owner of the commercial rights to the article&nbsp; is&nbsp; the author.</p> https://hmpublisher.com/index.php/OAIJMR/article/view/686 <p>Atherosclerosis, a chronic inflammatory disease, is the leading cause of cardiovascular disease. Interleukin-6 (IL-6) plays a crucial role in atherogenesis, making it a potential therapeutic target. Tocilizumab, an IL-6 receptor antagonist, has shown promise in reducing inflammation and stabilizing atherosclerotic plaques. This meta-analysis aimed to evaluate the efficacy and safety of tocilizumab in atherosclerosis by analyzing its impact on inflammatory markers and plaque characteristics. A systematic search of PubMed, Embase, and Cochrane Central Register of Controlled Trials was conducted from January 2013 to January 2024. Studies evaluating the effects of tocilizumab on inflammatory markers and plaque characteristics in patients with atherosclerosis were included. Randomized controlled trials (RCTs) and observational studies with a comparative arm were eligible. Data were extracted and pooled using a random-effects model. Nine studies (n=1248 participants) met the inclusion criteria. Tocilizumab significantly reduced CRP levels (standardized mean difference [SMD] -1.23; 95% confidence interval [CI] -1.56 to -0.90; p&lt;0.001) and IL-6 levels (SMD -0.87; 95% CI -1.12 to -0.62; p&lt;0.001) compared to control groups. A significant reduction in plaque volume (SMD -0.45; 95% CI -0.71 to -0.19; p=0.001) and an increase in fibrous cap thickness (SMD 0.38; 95% CI 0.12 to 0.64; p=0.004) were also observed. No significant increase in adverse events was reported in the tocilizumab group. This meta-analysis demonstrates that tocilizumab effectively reduces inflammation and promotes plaque stabilization in atherosclerosis. These findings suggest that tocilizumab may be a promising therapeutic strategy for preventing cardiovascular events in patients with atherosclerosis. Further large-scale RCTs are needed to confirm these findings and establish the long-term safety and efficacy of tocilizumab in this population.</p> Ali Zainal Abidin Tri Nisdian Wardiah Taufik Indrajaya Nur Riviati Copyright (c) 2025-01-22 2025-01-22 5 1 902 915 10.37275/oaijmr.v5i1.686 https://hmpublisher.com/index.php/OAIJMR/article/view/689 <p>Anterior cervical discectomy and fusion (ACDF) is a surgical procedure performed to alleviate pressure on the spinal cord and nerve roots in the neck. Effective pain management is crucial for optimal postoperative recovery. Superficial cervical plexus block (SCPB) has emerged as a safe and effective regional anesthesia technique for head and neck surgeries. This case report describes the successful use of ultrasound-guided SCPB for ACDF in a patient with a herniated nucleus pulposus. In this study, a 48-year-old male patient presented with lower extremity weakness and hypoesthesia following a fall. Magnetic resonance imaging (MRI) revealed a herniated nucleus pulposus at the C5-6 level. The patient underwent ACDF surgery under ultrasound-guided SCPB. Levobupivacaine 0.5% 10 cc was administered bilaterally. The patient tolerated the procedure well, with no complications or adverse events. Postoperative pain was effectively managed with SCPB, and the patient's neurological symptoms improved significantly. In conclusion, ultrasound-guided SCPB is a safe and effective anesthetic technique for ACDF surgery in patients with herniated nucleus pulposus. It provides adequate pain control, reduces opioid requirements, and facilitates early mobilization and recovery.</p> Elanda Rahmat Arifyanto Aura Ihsaniar Copyright (c) 2025-01-23 2025-01-23 5 1 916 929 10.37275/oaijmr.v5i1.689