Open Access Indonesian Journal of Medical Reviews https://hmpublisher.com/index.php/OAIJMR <p><strong>Open Access Indonesian Journal of Medical Reviews (OAIJMR)&nbsp;</strong>is a bi-monthly, international, peer-review, and open access journal dedicated to various disciplines of medicine, biology and life sciences. The journal publishes all type of review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review. <strong>OAIJMR</strong> is an official journal of&nbsp;<a href="https://cattleyacenter.id/" target="_blank" rel="noopener">CMHC (Research &amp; Sains Center)</a>&nbsp;and &nbsp;<a href="https://cattleyapublicationservices.com/hanifmedisiana/" target="_blank" rel="noopener">HM Publisher</a>. <strong>OAIJMR</strong> has <a href="https://issn.brin.go.id/terbit/detail/20210827121715854" target="_blank" rel="noopener">electronic ISSN (eISSN) : 2807-6257</a>. <strong>OAIJMR</strong> has <a href="https://portal.issn.org/resource/ISSN/2807-6257#" target="_blank" rel="noopener">International ISSN (ROAD) : 2807-6257</a>.</p> en-US <p><strong>Open Access Indonesian Journal of Medical Reviews (OAIJMR)&nbsp;</strong>allow the author(s) to hold the copyright without restrictions and&nbsp; allow the author(s) to retain publishing rights without restrictions, also the owner of the commercial rights to the article&nbsp; is&nbsp; the author.</p> indonesian.medical.reviews@gmail.com (HM Publisher) indonesian.medical.reviews@gmail.com (HM Publisher) Thu, 01 Feb 2024 00:00:00 +0000 OJS 3.1.2.4 http://blogs.law.harvard.edu/tech/rss 60 Optimization and Characterization of Fenofibrate Self-Nanoemulsifying Drug Delivery System (SNEDDS) Preparations https://hmpublisher.com/index.php/OAIJMR/article/view/451 <p>Fenofibrate is a third-generation fibric acid derivative included in BCS (biopharmaceutical classification system) class II, namely high permeability, low solubility. This research aims to obtain the optimum formula for miglyol oil, cremophor RH 40 and PEG 400 according to characterization tests of emulsification time, % transmittance, drug loading, globule size, and zeta potential. This research is an experimental study by formulating fenofibrate in the form of SNEDDS, which was made in 16 formulas using the D-optimal method, which was formulated in the form of SNEDDS with the composition miglyol, cremophor RH 40 and PEG 400 and characterization tests were carried out for emulsification time, % transmittance, drug loading, size. globules, zeta potential to obtain the optimum formula, and then analyzed using the one sample T-Test. The optimization results obtained the optimum formula, namely miglyol at 4%; cremophor RH 40 is 5%, and PEG 400 at 1%. Characterization test: emulsification time was 24 seconds, Transmittance % was 98.7%, Drug loading was 181 mg, globule size was 126 nm, and zeta potential of 12.26 mV. The dissolution test of the fenofibrate capsule dissolved 57.05%, while the fenofibrate SNEDDS capsule was 64.86%. This means that the dissolution of the optimum formula for SNEDDS fenofibrate is better than pure fenofibrate.</p> Sukarno, Ilham Kuncahyo, Endang Dyah Ikasari Copyright (c) https://hmpublisher.com/index.php/OAIJMR/article/view/451 Mon, 01 Jan 2024 00:00:00 +0000 Formulation and Characterization of Mefenamic Acid Self Nanoemulsifying Drug Delivery System (SNEDDS) Preparations https://hmpublisher.com/index.php/OAIJMR/article/view/461 <p>Mefenamic acid is included in BCS (biopharmaceutical classification system) class II, namely high permeability and low solubility. This research aims to obtain a good formula for oleic acid oil, tween 80, and PEG 400 according to the characterization test of emulsification time, % transmittance, drug loading, globule size, and zeta potential. This research was an experimental study by formulating mefenamic acid in the form of SNEDDS which was made 1 formula was made in the form of SNEDDS with the composition of oleic acid, tween 80, and PEG 400 and characterization tests were carried out for emulsification time, % transmittance, drug loading, globule size, zeta potential. The yield of the oleic acid formula is 1%, tween 80 is 8%, and PEG 400 is 1%. The emulsification time characterization test resulted in 17 seconds, % transmittance of 97%, drug loading of 179.81 mg, globular size of 85.8 nm and zeta potential of -1.6 mV.</p> Farrah Bintang Sabiti, Sukarno Copyright (c) https://hmpublisher.com/index.php/OAIJMR/article/view/461 Mon, 08 Jan 2024 05:58:58 +0000 Management Evaluation of Expired and Slow-Moving Medications at Hospital X in Batam City https://hmpublisher.com/index.php/OAIJMR/article/view/504 <p>Efficient drug management necessitates a well-structured supply chain to ensure the smooth functioning of health services. The objective of this study is to ascertain the strategies employed for the disposal of expired medications and the handling of slow-moving pharmaceuticals at Hospital X in Batam City. This research is characterized as descriptive-observational, employing a retrospective methodology. Data analysis involves doing qualitative analysis to assess the degree of rationality, followed by quantitative analysis using a formula. The findings of this study indicate that the highest proportion of expired pharmaceuticals occurred in September 2021, accounting for 25.011%. Additionally, the Regional Public Service Agency (RPSA) allocated 17.020% of the budget expenditures, while the Regional Budget (RB) allocated 28.904%. The pharmaceuticals that have the highest expiration rate are injectable preparations, with a proportion of 63.340%. Among these, 41.299% are funded by RPSA, and 74.075% are funded by RB. The highest proportion of expired pharmaceuticals, categorized by therapeutic class, is 16.500% in the antibiotic group. In addition, RPSA allocates 6.729% of the budget funds and RB allocates 37.123% of the budget for this purpose. The highest proportion of expired pharmaceuticals, categorized by therapeutic class, is 16.500% in the antibiotic group. In addition, RPSA allocates 6.729% of its budget funds and RB allocates 37.123% of its budget towards these expired drugs. In the first quarter, there were 57 slow-moving medications, accounting for 84.594% of the budget money from RPSA and 15.406% from RB. The findings of this study indicate that the management of expired pharmaceuticals does not meet the research criterion of less than 1%; however, the management of slow-moving drugs aligns with the research criterion of less than 1%.</p> Putri Meisa Anggesta, Heldi Candra, Fifin Oktaviani Copyright (c) https://hmpublisher.com/index.php/OAIJMR/article/view/504 Mon, 29 Jan 2024 04:01:12 +0000 Evaluation of Vaccine Stock Management at the Karanganyar Regency Health Service Indonesia https://hmpublisher.com/index.php/OAIJMR/article/view/506 <p>Vaccines are very susceptible to damage, so vaccine management requires special handling, this is done to maintain vaccine quality. The aim of this research is to find out the description and evaluate suitability vaccine management at the Karanganyar Regency Health Service (DKK) in 2022 based on Minister of Health Regulation No. 12 of 2017. This research is a qualitative descriptive non-experimental research. These research methods cross sectional by using approach, observation or data collection. The sampling technique uses accidental sampling by reviewing and evaluating vaccine management, which includes planning, procurement, receipt, storage, and distribution at the Karanganyar Health Service. The method used for data collection uses checklist suitability and in-depth interviews with the Head of Installation and pharmacy officers. Vaccine planning is adjusted to the usage index and needs in the previous year using a combined method system top to bottom and bottom up. Vaccine procurement is centralized at the Provincial Health Service, where requests are made by method bottom up. Receiving the vaccine is not immediate drop from the center/province, but the Karanganyar DKK takes the needed vaccines to the Provincial Health Service using the provisions for good drug distribution methods. Vaccine storage and distribution at DKK Karanganyar is in accordance with Minister of Health Regulation number 12 of 2017 and also in accordance with vaccine management guidelines from the Ministry of Health in 2021. Vaccines at DKK Karanganyar are in accordance with Minister of Health Regulation number 12 of 2017 and also in accordance with vaccine management guidelines from the Ministry of Health in 2021, both in planning, procurement, receipt, storage and distribution.</p> Andre Kurniawan, Jason Merari Peranginangin, Samuel Budi Harsono Copyright (c) https://hmpublisher.com/index.php/OAIJMR/article/view/506 Fri, 02 Feb 2024 09:05:07 +0000 Analysis of Drug Management and Improvement Strategies Using the Hanlon Method at the Pharmacy Installation of Dr. Oen Kandang Sapi Hospital, Surakarta, Indonesia https://hmpublisher.com/index.php/OAIJMR/article/view/530 <p>Medication management is an important factor in ensuring the level of drug availability. The aim of this research is to analyze and provide strategies for improving drug management in the Pharmaceutical Installation of Dr. Oen Kandang Sapi Hospital Surakarta using the Hanlon method. This research uses a descriptive design, with data taken retrospectively and concurrently. Data was obtained from the selection, procurement, distribution, and use stages. In the selection stage, the results obtained were drug suitability with the National Formulary (65.14%) and suitability with the Hospital Formulary (75.07%); Procurement stage: frequency of procurement per year (96 times), frequency of delayed payments from hospitals (0 time). In the distribution stage, the percentage of expired date medicines damaged (0.15%), the accuracy of the data on the number of medicines on the stock card was (95.78%), and the percentage of dead stock (3.61%). Stage of use: number of items per prescription sheet (3.18 sheets), percentage of antibiotic drug prescriptions (8.53%), percentage of injection drug prescriptions (29.86%), the average time to serve prescriptions (non-concocted 8.88 minutes and concocted 17.52 minutes), the percentage of drugs that can be submitted (99.95%), percentage of drugs that are fully labeled (100%). Percentage of prescriptions with generic names (49.26%). The results of analysis using the Hanlon method show that drug management in the Pharmacy Installation of Dr. Oen Kandang Sapi Hospital Surakarta is quite good but needs to be improved continuously.</p> Cakka Kumara Vidya Dharma, Titik Sunarni, Ika Purwidyaningrum Copyright (c) https://hmpublisher.com/index.php/OAIJMR/article/view/530 Tue, 27 Feb 2024 03:12:38 +0000