Acute Toxicity Testing of White Turmeric Extract (Curcuma zedoaria) on Histopathological Imaging of the Lungs

Authors

  • Ainge Rasbina Br Saragih Medical Education Study Program, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia
  • Fiska Maya Wardhani Medical Education Study Program, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia
  • Erny Tandanu Medical Education Study Program, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia
  • Rico Alexander Medical Education Study Program, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia

DOI:

https://doi.org/10.37275/amcr.v2i4.125

Keywords:

Diabetes mellitus, Diabetic foot, Hyperglycemia, Neuropathy, Body mass index

Abstract

White turmeric (Curcuma zedoaria) is a type of plant whose extract contains compounds that can inhibit carcinogenesis. Acute toxicity test was conducted to determine the safe dose and lethal dose (LD) 50 from the use of a drug substance. This research aimed to determine the effect of the acute toxicity test of white turmeric extract on the histopathological imaging of the lungs. This study is an experimental study with a post test only control group design. A total of 30 Wistar rats was divided into six groups. Data analysis was using one-way ANOVA statistical test, while for lung histopathology using ordinal data which were analyzed descriptively. In conclusion, the acute toxicity test of white turmeric extract on Wistar rats was not toxic and there was no death and no toxic symptoms and no necrosis, congestion and inflammation were found on the histopathological picture of the lungs.

Authors

  • Ainge Rasbina Br Saragih1
  • Fiska Maya Wardhani1
  • Erny Tandanu1*
  • Rico Alexander1
  1. 1Medical Education Study Program, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia

Corresponding author Erny Tandanu — ernytandanu@unprimdn.ac.id

Downloads

Published

2021-11-09

Issue

Vol. 2 No. 4 (2021): Archives of The Medicine and Case Reports

Section

Articles

License

Authors retain copyright and grant Archives of The Medicine and Case Reports (AMCR) the right of first publication. Published articles are licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0). This license permits users to copy, redistribute, and adapt the work for non-commercial purposes, provided that appropriate credit is given, a link to the license is supplied, changes are indicated, and adaptations are distributed under the same license. Copyright in the journal website, logo, layout, and other publisher-owned materials does not transfer copyright in individual articles.

How to Cite

Acute Toxicity Testing of White Turmeric Extract (Curcuma zedoaria) on Histopathological Imaging of the Lungs. (2021). Archives of The Medicine and Case Reports, 2(4), 195-200. https://doi.org/10.37275/amcr.v2i4.125

Article Metrics

815Abstract views
423Downloads
0Citations

Views and downloads recorded by this journal. Citation count from OpenAlex.