Successful Management of Grade III Tetanus with Therapeutic Plasma Exchange: A Case Report
DOI:
https://doi.org/10.37275/jacr.v5i3.644Keywords:
Grade III tetanus, Intensive care, Plasmapheresis, Tetanus, Therapeutic plasma exchangeAbstract
Introduction: Tetanus, a severe neurologic disorder caused by Clostridium tetani neurotoxin, presents with progressive muscle rigidity and spasms. Grade III tetanus, characterized by generalized tetanus with severe spasms, carries a high mortality risk. Therapeutic plasma exchange (TPE) has emerged as an adjunctive therapy to remove circulating toxins and inflammatory mediators.
Case presentation: We report a 50-year-old male with grade III tetanus following a minor injury. Despite standard treatment with tetanus immunoglobulin, antibiotics, and muscle relaxants, his condition deteriorated, necessitating intensive care unit (ICU) admission and mechanical ventilation. The patient underwent two sessions of TPE, demonstrating significant clinical improvement with reduced muscle spasms and successful ventilator weaning.
Conclusion: This case highlights the potential benefit of TPE in managing severe tetanus, particularly in cases refractory to conventional therapy. Early recognition and aggressive management, including TPE, can improve outcomes in this life-threatening condition.
Authors
- Jati Febriyanto Adi Listyono Putro1*
- Andy Nugroho1
- Septian Adi Permana1
- Andi Hermawan1
- 1Department of Anesthesiologist and Intensive Care Therapy, Faculty of Medicine, Universitas Sebelas Maret/Dr. Moewardi Regional General Hospital, Surakarta, Indonesia
Corresponding author Jati Febriyanto Adi Listyono Putro — jatifal@gmail.com
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