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At the end of 2019, the coronavirus infection pandemic shocked the world. This virus began with reports of infections in the Wuhan area, China. The death rate from COVID-19 infection can reach 3%; however, the mortality rate in critically ill patients with COVID-19 infection is much higher, reaching 61.5%. This study was aimed to summarize the neuropsychiatric impact and neuropathological mechanisms of COVID-19 infection. The primary manifestation of COVID-19 infection is respiratory tract infection. Coronavirus can penetrate the central nervous system and cerebrospinal fluid in less than a week. Histopathological examination of the brain of the deceased COVID-19-19 showed the potential for SARS-CoV-2 to infect the central nervous system (CNS). Neuroinflammation can also damage blood brain barrier. Several patients treated with COVID-19-19 infection exhibited confusion and agitation without respiratory symptoms or other signs of infection. The COVID-19 pandemic not only directly impacts infected individuals but has also caused a new wave of psychological stress in society.


Agitation COVID-19 Inflammation Neuropathology Neuropsychiatric Respiratory disorder

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How to Cite
Fitriani, D. (2021). Overview of COVID-19 Infection Manifestation in Neuropsychiatry Aspect. Open Access Indonesian Journal of Medical Reviews, 1(3), 48-52.