Formulation and Characterization of Mefenamic Acid Self Nanoemulsifying Drug Delivery System (SNEDDS) Preparations

Authors

  • Farrah Bintang Sabiti Pharmacist Professional Education Study Program, Faculty of Pharmacy, Universitas Islam Sultan Agung, Semarang, Indonesia
  • Sukarno ITEKES Cendekia Utama, Kudus, Indonesia

DOI:

https://doi.org/10.37275/oaijmr.v4i1.461

Keywords:

% Transmittance, Drug loading, Emulsification time, Globule size, Mefenamic acid

Abstract

Mefenamic acid is included in BCS (biopharmaceutical classification system) class II, namely high permeability and low solubility. This research aims to obtain a good formula for oleic acid oil, tween 80, and PEG 400 according to the characterization test of emulsification time, % transmittance, drug loading, globule size, and zeta potential. This research was an experimental study by formulating mefenamic acid in the form of SNEDDS which was made 1 formula was made in the form of SNEDDS with the composition of oleic acid, tween 80, and PEG 400 and characterization tests were carried out for emulsification time, % transmittance, drug loading, globule size, zeta potential. The yield of the oleic acid formula is 1%, tween 80 is 8%, and PEG 400 is 1%. The emulsification time characterization test resulted in 17 seconds, % transmittance of 97%, drug loading of 179.81 mg, globular size of 85.8 nm and zeta potential of -1.6 mV.

Authors

  • Farrah Bintang Sabiti1
  • Sukarno2*
  1. 1Pharmacist Professional Education Study Program, Faculty of Pharmacy, Universitas Islam Sultan Agung, Semarang, Indonesia
  2. 2ITEKES Cendekia Utama, Kudus, Indonesia

Corresponding author Sukarno — sukarnosukarno1995@gmail.com

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Published

2024-01-08

Issue

Vol. 4 No. 1 (2024): Open Access Indonesian Journal of Medical Reviews

Section

Articles

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How to Cite

Formulation and Characterization of Mefenamic Acid Self Nanoemulsifying Drug Delivery System (SNEDDS) Preparations . (2024). Open Access Indonesian Journal of Medical Reviews, 4(1), 561-565. https://doi.org/10.37275/oaijmr.v4i1.461

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